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Drug discovery and development underwent a major breakthrough during the late 1990's with the advent of genomics. Magellan Pharmaceutical Development has kept pace with this revolution and continues to provide state of the art support to your programs by recruiting recognized experts to its Research and Bioanalytical Laboratories. Our high throughput collection of assays covers all facets of drug discovery, absorption, metabolism, toxicology and pharmacokinetics while also supplying genomic-based technologies to meet your research needs.

We stand ready to help. Take a look at the services below to acquaint yourself with our broad range of capabilities.

Please give us a call with any questions or submit a project to us online.

Idea Generation

  • Gene Expression
  • Mutagenesis
  • Cloning

Hit Identification

  • Therapeutic Focus
    • High Throughput Screen
    • ELISA
    • Receptor Binding Assays
    • Modulation of gene expression (branched DNA screen)
  • In vitro Activity Confirmation
    • Specificity/Selectivity Assays
    • Cell Based Methods
    • Western Blots
    • Apoptosis
    • Signal Transduction

Lead Selection (In vitro high-throughput assays)

  • Predictive ADME
    • Caco2 and MDCK Permeability
    • Solubility Testing
    • P450 Inhibition Screening
    • P450 Metabolic Stability
  • Predictive Toxicology
    • QTc Prolongation: HERG and Purkinje Fiber (GLP)
    • Mutagenesis: AMES II, AMES (GLP) and Chromosomal Aberration (GLP)
    • Genotoxicity (i.e. COMET assay)

Lead Optimization (Reaction Phenotyping, GLP and non-GLP)

  • Phase I Metabolism-Oxidation
  • Phase II Metabolism-Glucoronidation, Sulfation, N-acetylation
  • Selection of PK Animal Model
  • Metabolite Identification (Ion Trap LC/MS, LC/MS/MS, LC/NMR)
  • Metabolite Profiling
  • P450 Isozyme-Dependent Metabolism
  • Drug/Drug Interaction
  • P450 Inhibition-IC50 and Ki Determination
  • P450 Induction-Hepatocytes
  • Protein Binding

Pre-Clinical and Clinical Lead Development (GLP)

  • Pharmacogenomics
    • SNP Analysis
  • Surrogate Marker Analysis
    • Enzymatic Activity
  • Bioanalytical and analytical immunoassays, including ELISA Bioassays
    • Cell Growth and Inhibition
    • Cytokine Induction and Inhibition
    • Neutralization Assays
  • Cloning and Cell Banking

Benefits of Outsourcing with Magellan's Drug Discovery & Bioassay Laboratories:

Together, we will:

  • Optimize your productivity in the discovery and development of new drugs.
  • Design programs to identify new efficacious and safe compounds.
  • Provide bioanalytical support to all phases of drug discovery and development.
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